Finding your dose

Starting LUMRYZ^®

Two people playing guitar in a living room

Once you and your healthcare provider have decided LUMRYZ is right for you, they will work with you to consider the best way to start treatment*

Starting with LUMRYZ

If you ARE NOT currently taking an oxybate:

Your healthcare provider may start you on the lowest dose of LUMRYZ and increase your dose gradually over time until you reach the dose that’s right for you.

Switching to LUMRYZ

If you ARE currently taking an oxybate:

Your healthcare provider may switch you to the closest dose—equal to the amount of medicine you’re taking now.

Note: If you often miss your second nightly dose, be sure to tell your healthcare provider so they can determine your appropriate starting dose.

*For pediatric dosing, please see the full Prescribing Information.

It may take time before noticing a difference with LUMRYZ

In the clinical trial, some people saw improvement in their symptoms by week 3 on a 6 g dose, while others saw improvement at week 13 on the 9 g dose.^†

^†The LUMRYZ double-blind, placebo-controlled clinical trial included adults with narcolepsy treated with LUMRYZ (n=107). The results measured at Week 3 (n=88), Week 8 (n=77), and Week 13 (n=69) showed daytime symptom improvement of people on the 6 g, 7.5 g, and 9 g doses of LUMRYZ, respectively. Individual results may vary.

Melanie

Green quote

“I think it's important to stay in contact with your healthcare team when you start a new treatment. Early after starting LUMRYZ, I shared with my healthcare team how I was feeling (side effects and my symptoms). This information helped my healthcare team and me discuss adjustments to my treatment plan.”

MELANIE
living with narcolepsy and treating with LUMRYZ

Melanie was compensated by Alkermes for her time. Individual results may vary.

Because everyone’s experience is different, it’s important to share all your narcolepsy symptoms, goals, and treatment experiences with your healthcare team.

Looking for more information about LUMRYZ?

Hear from people living with narcolepsy and treating with LUMRYZ

Visit “Real LUMRYZ stories”

Explore the support available on your journey

Visit “RYZUP^® Support Services”

INDICATIONS

LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in patients 7 years of age and older with narcolepsy:

sudden onset of weak or paralyzed muscles (cataplexy)
excessive daytime sleepiness (EDS)

IMPORTANT SAFETY INFORMATION

WARNING: Taking LUMRYZ^® (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

Do not take LUMRYZ if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself. Call your doctor right away if you or your child have symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you or your child start sleepwalking.

Tell your doctor if you or your child are on a salt-restricted diet or have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.

LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.