Coverage and financial assistance

LUMRYZ^® coverage and financial assistance

greater than 90%

LUMRYZ is covered for greater than 90% of commercially insured patients*

RYZUP Support Services provides several programs that
support access to LUMRYZ

$0 copay

LUMRYZ Co-Pay Program:

With the LUMRYZ co-pay program, most patients with commercial insurance pay a $0 co-pay for LUMRYZ.^†

Your specialty pharmacy will automatically apply co-pay savings if your commercial insurance qualifies

LUMRYZ Quick Start Program:

If you are starting LUMRYZ and there is an initial denial or delay in your insurance approving your treatment, you may be able to receive medication at no cost.^‡

LUMRYZ Bridge Program:

If you are already taking LUMRYZ and have an interruption in coverage due to your insurance, you may be able to receive your medication at no cost.^‡

Patient Assistance Program (PAP):

If you are uninsured or underinsured, you may be eligible to receive LUMRYZ at no cost.^§

*Prior authorization may be required. This information is current as of 07/2026 and is subject to change. This is not a guarantee of payment coverage or reimbursement. Actual coverage and reimbursement decisions are made by the health plan. Contact the health plan for complete and current information regarding coverage of LUMRYZ.

^†This offer is valid only for patients who have commercial insurance and a qualifying LUMRYZ prescription. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Maximum benefit limits per prescription and annual benefit limits (“Annual Program Maximum”) per individual apply. Patients’ out-of-pocket expenses may vary. Additional terms and conditions apply. Download the full terms and conditions of the co-pay program.

^‡Applies only to eligible, commercially insured patients. Additional terms and conditions apply.

^§PAP application required. Patient must meet certain financial and other criteria.

If your insurance situation ever changes, we will help you navigate benefits investigations and connect you with any LUMRYZ financial assistance you may qualify for.

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INDICATIONS

LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in patients 7 years of age and older with narcolepsy:

sudden onset of weak or paralyzed muscles (cataplexy)
excessive daytime sleepiness (EDS)

IMPORTANT SAFETY INFORMATION

WARNING: Taking LUMRYZ^® (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

Do not take LUMRYZ if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself. Call your doctor right away if you or your child have symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you or your child start sleepwalking.

Tell your doctor if you or your child are on a salt-restricted diet or have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.

LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.