How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways: • Immediate-release granules start working as you fall asleep • Controlled-release granules start working later in place of waking for a second dose

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions For Use on how to prepare, shake, and take LUMRYZ.

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ REMS and RYZUP™. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Are any financial assistance programs available?

Yes, RYZUP Support Services are dedicated to helping you throughout your treatment journey, including financial assistance services such as co-pays as little as $0 if you’re eligible.*

What are the most common side effects?

The most common side effects reported by participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

What is Narcolepsy? | LUMRYZ™ (sodium oxybate)

Symptoms of narcolepsy are often missed and misunderstood

This can make narcolepsy feel like an “invisible condition”

It can take 8-15 years from when symptoms first start to receive an accurate diagnosis.

Some people with narcolepsy may even experience social stigma from those who don’t understand the condition.

However, you are not alone.

Narcolepsy affects over 168,000 adults and children in the United States.

“Excessive daytime sleepiness became this voice I couldn’t ignore that said, ‘I need to go to sleep, I am too tired to be here right now.’

I wasn’t skipping out on activities I enjoyed because I wasn’t interested in them anymore—but because my body was telling me I had no choice but to sleep.”
– Katie L., living with narcolepsy

Katie was compensated by Avadel Pharmaceuticals
for her time. Individual results may vary.

See Katie’s journey with narcolepsy

With narcolepsy, you may be facing disruptions around the clock

24/7 IMPACT

Narcolepsy is a chronic sleep disorder. It affects the brain’s ability to control your sleep-wake cycles—disrupting both your days and nights.

Two common symptoms of narcolepsy are excessive daytime sleepiness (EDS) and cataplexy

EDS

A persistent feeling of sleepiness that disrupts your day no matter how much you slept the night before
Usually the first symptom people notice
Can occur at random, like a sudden sleep attack, even when driving or talking
Can also occur during less active situations such as when watching TV
Is sometimes mistaken for a symptom of a different condition or goes unnoticed

Cataplexy

Sudden attacks of muscle weakness often triggered by strong emotions
Can be mild and feel like knees buckling, or as severe as full body paralysis
Usually lasts for a few seconds or minutes
May look different in children than in adults: for children, it can involve changes in the way they walk or weakness in their facial muscles
Can develop years after symptoms of EDS first start

Individuals featured have been compensated by Avadel. Individual results may vary.

“Before starting treatment, even if I slept a full 8, sometimes 10, hours, I would still fall asleep the next day during class and have to take naps.”

– Tyler F., living with narcolepsy

“I wish cataplexy was a word that everybody knew. Before starting treatment, my experiences with cataplexy could range from tingles in my arms and legs to being unable to move. It’s a vulnerable feeling.”

– Wendy B., living with narcolepsy

Managing your narcolepsy symptoms may be challenging

Current treatment options may cause or even require interruptions in sleep

Other oxybate options require waking up in the middle of the night to take a second dose.

Daytime treatments approved to treat narcolepsy may cause insomnia.

Use these discussion guides to help start a conversation with your healthcare provider about your narcolepsy treatment options.

Use this guide if you are new to oxybates.

Download

Use this guide if you are currently taking an oxybate.

Download

Pulmonologists
Neurologists

Psychiatrists
Pediatric Neurologists

If you are not already seeing a sleep specialist, your healthcare provider may refer you to one if necessary.

When talking with your healthcare team, it’s important to discuss all of your narcolepsy symptoms, goals, and treatment experiences so that you can work together to find the best treatment fit for you.

Have a consistent routine

Try to go to bed around the same time every night

Wake up around the same time every morning

Create a peaceful environment

Find ways to make your room a place that welcomes sleep

Find ways to reduce stress and relax your mind before bed

Make sleep a priority

Build a schedule around your checklist for healthy sleep habits

Keep a sleep journal to help identify what you may want to discuss with your healthcare provider

Remember to talk about your lifestyle, diet, exercise, and sleep when discussing treatment options with your healthcare provider.

INDICATIONS

LUMRYZ (sodium oxybate) for extended-release oral suspension is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy.

sudden onset of weak or paralyzed muscles (cataplexy)

excessive daytime sleepiness (EDS)

Important Safety Information

WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

Do not take LUMRYZ if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself. Call your doctor right away if you or your child have symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you or your child start sleepwalking.

Tell your doctor if you or your child are on a salt-restricted diet or have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. The most common side effects in children include nausea, bedwetting, vomiting, headache, decreased weight, decreased appetite, dizziness, and sleepwalking.

LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Symptoms of narcolepsy are often missed and misunderstood