How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways: • Immediate-release granules start working as you fall asleep • Controlled-release granules start working later in place of waking for a second dose

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions For Use on how to prepare, shake, and take LUMRYZ.

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ REMS and RYZUP™. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Are any financial assistance programs available?

Yes, RYZUP Support Services are dedicated to helping you throughout your treatment journey, including financial assistance services such as co-pays as little as $0 if you’re eligible.*

Why LUMRYZ | LUMRYZTM Sodium Oxybate

Proven daytime symptom treatment of cataplexy or excessive daytime sleepiness (EDS).
No waking for a second dose

LUMRYZ continues working throughout the course of your sleep cycle

A single, once-at-bedtime treatment means no interrupting your sleep to take a second dose

LUMRYZ levels, showing a continuous slope of medicine entering and being processed by the body

Access a free summary of the LUMRYZ clinical trial.

Click here

Once-at-bedtime LUMRYZ is proven to improve daytime symptoms of cataplexy or EDS*

People who received LUMRYZ experienced:

REDUCED EDS Stayed awake 1.5x longer

REDUCED CATAPLEXY ATTACKS 57% fewer cataplexy attacks

IMPROVED SYMPTOMS 73% were rated by clinicians to be much or very much improved

IMPROVEMENTS IN WEEKS Significant improvements as soon as 3 weeks into the trial^†

*These results, measured at weeks 3, 8, and 13, show daytime symptom improvement of participants on the 6-g, 7.5-g, and 9-g dose of LUMRYZ in a clinical trial.
^†As seen in participants taking a 6-g dose of LUMRYZ.

LUMRYZ once-at-bedtime dosing was found to be a major contribution to patient care.

The FDA has determined LUMRYZ to be clinically superior^‡ to both XYREM^® (sodium oxybate) and XYWAV^® (calcium, magnesium, potassium, and sodium oxybates):

“LUMRYZ once-at-bedtime dosing does not disrupt or fragment sleep”
- “XYREM and XYWAV require waking up to take a second dose during the night”
“LUMRYZ is more convenient, easier and less burdensome vs having to wake up for a second dose on a nightly basis. This is important as narcolepsy may require lifelong treatment”

^‡Based on a determination of Orphan Drug Exclusivity by the FDA OOPD between LUMRYZ and XYREM or XYWAV. There are no head-to-head data for LUMRYZ and XYREM or XYWAV.
OOPD, Office of Orphan Products Development.

With daytime symptom treatment and no middle-of-the-night dosing, LUMRYZ can help make a night and day difference.

Download the Doctor Discussion Guide to help you get ready for your next appointment.

Download

“Since starting once-at-bedtime LUMRYZ, I feel less sleepy and more awake during the day. I love to get up in the morning and read and write.”
– Wendy B., living with narcolepsy and treating with LUMRYZ

Wendy was compensated for her story. Individual results may vary.

See more about Wendy's experience with LUMRYZ

Side Effects of LUMRYZ

The most common side effects reported by participants in the clinical trial were:

Nausea • Dizziness • Bedwetting • Headache • Vomiting

The most common side effect leading to discontinuation was dizziness.

In the clinical trial, side effects typically occurred when participants started a new dose. Generally, the side effects declined over time while staying on the same dose
People who took the medicine experienced no clinically meaningful changes in heart rate or blood pressure between the start and the end of the trial

If you’re currently taking an oxybate to treat narcolepsy, talk to your doctor if switching to once-at-bedtime LUMRYZ is an option for you.

LUMRYZ may not be appropriate for some people with narcolepsy. Your doctor can help determine if LUMRYZ is a good fit for you.

Learn what to expect when starting LUMRYZ

Important Safety Information

WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

INDICATIONs

LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in adults with narcolepsy:

sudden onset of weak or paralyzed muscles (cataplexy)

excessive daytime sleepiness (EDS)

It is not known if LUMRYZ is safe and effective in people less than 18 years of age.

Do not take LUMRYZ if you take other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you have or had depression or have tried to harm yourself. Call your doctor right away if you have symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you start sleepwalking.

Tell your doctor if you are on a salt-restricted diet or if you have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Proven daytime symptom treatment of cataplexy or excessive daytime sleepiness (EDS). No waking for a second dose