How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways: • Immediate-release granules start working as you fall asleep • Controlled-release granules start working later in place of waking for a second dose

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions For Use on how to prepare, shake, and take LUMRYZ.

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ REMS and RYZUP™. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Are any financial assistance programs available?

Yes, RYZUP Support Services are dedicated to helping you throughout your treatment journey, including financial assistance services such as co-pays as little as $0 if you’re eligible.*

What are the most common side effects?

The most common side effects reported by participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

RYZUP™ Support Services | LUMRYZ™ (sodium oxybate)

RYZUP^™ Support Services is your partner in care

We provide personalized support to help you access, start, and stay on track with your LUMRYZ treatment plan

Avadel Pharmaceuticals is committed to helping you start treatment with LUMRYZ. That’s why we offer support services to help in navigating access to LUMRYZ and provide financial assistance programs to those who qualify.

GETTING STARTED

Before you can begin LUMRYZ, your doctor’s office will start the process to enroll you into (1) RYZUP Support Services and (2) LUMRYZ REMS.

Shortly after signing the paperwork, you will receive a call from your personal RYZUP Nurse Care Navigator (NCN) to welcome you to the program, review the next steps in the process, and help connect you with any financial assistance you may qualify for.

Remember: You need to sign two (2) forms in order to access LUMRYZ. You may be asked to sign these forms in the doctor’s office or receive them by email for you to e-sign.
Note: You may receive each document in a separate email.

REMS, Risk Evaluation and Mitigation Strategy.

Nurse and Pharmacy Support

Your personal RYZUP NCN is dedicated to helping you start LUMRYZ and will be with you throughout your treatment journey.

When you’re ready to start taking LUMRYZ, your NCN will:

Help you navigate the insurance process and help connect you with any financial assistance you may qualify for.

Call you to review how to take the medication and answer any questions you may have. They will also coordinate with your REMS-certified specialty pharmacy to make sure you receive reminders when your LUMRYZ prescription needs to be refilled.

Find your dedicated NCN by entering your prescriber’s ZIP code below:

Meet your NCN:

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Angela Bell 1-913-396-7679

RYZUP Support Services offers financial assistance programs for those who qualify. Eligible patients may pay as little as $0 co-pay per month.*

*This offer is valid only for patients who have commercial insurance. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Additional terms and conditions apply. Download the full terms and conditions of the co-pay program.

Temporary Access Program (TAP)

If there is a delay in insurance coverage, you may be eligible for up to 120 days of free LUMRYZ.^†

Patient Assistance Program (PAP)

Treatment is available free of charge to eligible patients who are uninsured or underinsured.^‡

^†Applies only to eligible, commercially insured patients.
^‡PAP application required. Patient must meet certain financial and other criteria.

If your insurance situation ever changes, your NCN will help you understand any impact to your coverage and help connect you with any financial assistance you might qualify for.

RYZUP Resources

Co-pay Terms and Conditions
See Terms and Conditions for the LUMRYZ co-pay program.

Download

RYZUP Patient Authorization Form
Complete this form for enrollment in RYZUP after your doctor has prescribed LUMRYZ.

Download

RYZUP PAP Application
Complete this form after your doctor has prescribed LUMRYZ if you need financial assistance and are uninsured or underinsured.

Download

Important Safety Information

WARNING: Taking LUMRYZ™ (sodium oxybate) with other central nervous system (CNS) depressants such as medicines used to make you fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of LUMRYZ (sodium oxybate) is a form of gamma hydroxybutyrate (GHB), a controlled substance. Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you have any of these serious side effects.

Because of these risks, LUMRYZ is available only by prescription and filled through certified pharmacies in the LUMRYZ REMS program. You must be enrolled in the LUMRYZ REMS to receive LUMRYZ. Further information is available at www.LUMRYZREMS.com or by calling 1-877-453-1029.

INDICATIONs

LUMRYZ (sodium oxybate) for extended-release oral suspension is a prescription medicine used to treat the following symptoms in adults with narcolepsy:

sudden onset of weak or paralyzed muscles (cataplexy)

excessive daytime sleepiness (EDS)

It is not known if LUMRYZ is safe and effective in people less than 18 years of age.

Do not take LUMRYZ if you take other sleep medicines or sedatives (medicines that cause sleepiness), drink alcohol, or have a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep LUMRYZ in a safe place to prevent abuse and misuse. Selling or giving away LUMRYZ may harm others and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes LUMRYZ should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least six (6) hours after taking LUMRYZ. Those activities should not be done until you know how LUMRYZ affects you.

Falling asleep quickly, including while standing or while getting up from the bed, has led to falls with injuries that have required some people to be hospitalized.

LUMRYZ can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (eg, sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they take LUMRYZ.

Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, and difficulty concentrating. Tell your doctor if you have or had depression or have tried to harm yourself. Call your doctor right away if you have symptoms of mental health problems or a change in weight or appetite.

Sleepwalking. Sleepwalking can cause injuries. Call your doctor if you start sleepwalking.

Tell your doctor if you are on a salt-restricted diet or if you have high blood pressure, heart failure, or kidney problems. LUMRYZ contains a lot of sodium (salt) and may not be right for you.

The most common side effects of LUMRYZ in adults include nausea, dizziness, bedwetting, headache, and vomiting. Your side effects may increase when you take higher doses of LUMRYZ. LUMRYZ can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of LUMRYZ.

For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

RYZUP™ Support Services is your partner in care

We provide personalized support to help you access, start, and stay on track with your LUMRYZ treatment plan

GETTING STARTED

Nurse and Pharmacy Support

RYZUP Resources

Important Safety Information

INDICATIONs

The contents of this website are intended for patients.

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RYZUP^™ Support Services is your partner in care