Find answers to frequently asked questions about LUMRYZ

How does LUMRYZ work?

The active ingredient in LUMRYZ is sodium oxybate. But unlike other oxybate options, you don’t need to wake up in the middle of the night for a second dose. This is because LUMRYZ contains a unique blend of granules that work in 2 ways:

  • Immediate-release granules start working as you fall asleep
  • Controlled-release granules start working later in place of waking for a second dose

Learn more about LUMRYZ

Is LUMRYZ effective at treating narcolepsy?

Yes, LUMRYZ was shown to improve symptoms of cataplexy or excessive daytime sleepiness (EDS) with a once-at-bedtime dose.

See more results from the trial

Can I switch to LUMRYZ if I’m currently on a different oxybate?

Only your doctor can decide if LUMRYZ is right for you. LUMRYZ is approved for the treatment of cataplexy or EDS in adults with narcolepsy.

If you’re currently taking an oxybate, your doctor can switch you to LUMRYZ at the closest dose equal to what you’re taking now.

Learn how LUMRYZ is different

How should I take LUMRYZ?

With LUMRYZ, you take 1 premeasured packet, once at bedtime. See the Instructions for Use for how to prepare, shake, and take LUMRYZ.

Find more details and watch our step-by-step guide

How do I start a conversation with my doctor about LUMRYZ?

To help you start the conversation with your doctor, we created a Doctor Discussion Guide with key questions to ask your doctor and plenty of space to take notes.

Download Doctor Discussion Guide

How do I start on LUMRYZ?

LUMRYZ is only available after enrollment in the LUMRYZ Risk Evaluation and Mitigation Strategy (REMS) and RYZUP™ Support Services. Your doctor starts your enrollment, then you’ll need to fill out a few forms.

Find helpful forms and learn more about enrolling in RYZUP

What is the taste and texture of LUMRYZ?

Because of the mixed-release granules that make up the extended-release formula for LUMRYZ, your dose will have a gritty texture and salty taste. Some granules may stick together and look milky and lumpy even after being thoroughly shaken in the provided mixing cup.

See the Instructions for Use for more on what to expect when taking LUMRYZ.

What are the most common side effects?

The most common side effects reported by participants in the clinical trial were nausea, dizziness, bedwetting, headache, and vomiting.

Learn more about side effects

Are any financial assistance programs available?

Yes, RYZUP Support Services offers financial support programs for eligible patients, including co-pay assistance for commercially insured patients. Eligible patients may pay as little as $0 co-pay per month.*

See how RYZUP Support Services can help